Journal
CELL BIOLOGY INTERNATIONAL
Volume 30, Issue 11, Pages 915-919Publisher
WILEY
DOI: 10.1016/j.cellbi.2006.06.020
Keywords
cell transformation; core; NS3; HCV; p53
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The oncogenic potential of both Hepatitis C virus (HCV) core and HCV NS3 proteins has been demonstrated, but these proteins induce transformation of immortal murine fibroblasts NIH 3T3 via different pathways. As long-term expression (50-100 passages) of HCV core triggers neoplastic transformation of NIH 3T3 through crisis of growth, HCV NS3 induces transformation shortly after transfection. We explain this distinction by different effects of core and NS3 on p53-mediated transactivation: inhibition by NS3 and activation by core protein. (c) 2006 International Federation for Cell Biology. Published by Elsevier Ltd. All rights reserved.
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