Journal
CLINICS IN DERMATOLOGY
Volume 24, Issue 6, Pages 486-492Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.clindermatol.2006.07.010
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Multicentric reticulohistiocytosis is a rare granulomatous disease of unknown etiology, characterized by cutaneous nodules and destructive arthritis. Skin lesions can cause significant deformity, and approximately half of affected patients develop a severe disabling arthritis. The disease is often associated with malignancy; however, the paraneoplastic nature of multicentric reticulohistiocytosis is not established. The diagnosis is confirmed by the presence of oncocytic (ground-glass) histiocytes and multinucleated giant cells on histopathology of the cutaneous nodules and the synovial membrane. (c) 2006 Elsevier Inc. All rights reserved.
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