Journal
RADIATION RESEARCH
Volume 166, Issue 5, Pages 693-714Publisher
RADIATION RESEARCH SOC
DOI: 10.1667/RR0706.1
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Funding
- NCI NIH HHS [CA120098, CA80830, CA16038, CA 10006, R01 CA080830] Funding Source: Medline
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DNA polymerases function in DNA replication, repair, recombination and translesion synthesis. Currently, 15 DNA polymerase genes have been identified in human cells, belonging to four distinct families. In this review, we briefly describe the biochemical activities and known cellular roles of each DNA polymerase. Our major focus is on the phenotypic consequences of mutation or ablation of individual DNA polymerase genes. We discuss phenotypes of current mouse models and altered polymerase functions and the relationship of DNA polymerase gene mutations to human cell phenotypes. Interestingly, over 120 single nucleotide polymorphisms (SNIs) have been identified in human populations that are predicted to result in nonsynonymous amino acid substitutions of DNA polymerases. We discuss the putative functional consequences of these SNIs in relation to human disease. (c) 2006 by Radiation Research Society.
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