Journal
TRAFFIC
Volume 7, Issue 11, Pages 1440-1450Publisher
WILEY
DOI: 10.1111/j.1600-0854.2006.00488.x
Keywords
genomic RNA; retrovirus; ribonucleoprotein particle; RNA localization; RNA packaging; RNA transport; translation; virus assembly
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Funding
- Medical Research Council [G0401570] Funding Source: researchfish
- MRC [G0401570] Funding Source: UKRI
- Medical Research Council [G0401570] Funding Source: Medline
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Full-length retroviral RNA has three well-established functions: it constitutes the genomic RNA that is packaged into virions and is transmitted to target cells by infection, it is the messenger RNA (mRNA) template for viral Gag and Pol protein synthesis and it serves as the pre-mRNA for the production of subgenomic spliced mRNAs that encode additional viral proteins such as Env. More recent work indicates that these full-length RNAs also play important roles in the assembly of virus particles, not only as a structural scaffold that facilitates viral core formation but also as a potential regulator of the assembly process itself. Here, we discuss how these assorted activities may be coupled with each other, paying particular attention to the importance of RNA trafficking and subcellular localization in the cytoplasm, possible points of regulation, and the role(s) played by cellular RNA-binding proteins.
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