Journal
JOURNAL OF PHARMACOLOGICAL SCIENCES
Volume 102, Issue 3, Pages 354-358Publisher
JAPANESE PHARMACOLOGICAL SOC
DOI: 10.1254/jphs.SC0060118
Keywords
presenilin 1; SH-SY5Y cell; neuritogenesis
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Presenilin 1 (PS1) is a multifunctional protein, and its mutations are highly related to familial Alzheimer's disease (AD). In this study, we examined the effects of PS1 overexpression on neuronal morphology using SH-SY5Y cells. Overexpression of dominant-negative D385A PS1 induced morphological change and impairment of neurite formation, while those of wild-type and pathogenic P117L mutant PS1 did not change cellular morphology compared with native cells. Moreover, filopodium-formation-related proteins were decreased only in cells over-expressing D385A PS1. Therefore, PS1 may be involved in neuritogenesis and morphological change in SH-SY5Y cells, and P117L mutation may linked to AD by different mechanisms.
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