Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 7, Issue 11, Pages 833-846Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm2039
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The protein tyrosine phosphatase (PTP) superfamily of enzymes functions in a coordinated manner with protein tyrosine kinases to control signalling pathways that underlie a broad spectrum of fundamental physiological processes. In this review, I describe recent breakthroughs in our understanding of the role of the PTPs in the regulation of signal transduction and the aetiology of human disease.
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