Journal
BRITISH JOURNAL OF PSYCHIATRY
Volume 189, Issue -, Pages 459-460Publisher
ROYAL COLLEGE OF PSYCHIATRISTS
DOI: 10.1192/bjp.bp.105.008961
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Klinefelter's syndrome, characterised by a 47,XXYchromosomal pattern, has largely been associated with physical abnormalities. Here, we report high levels of schizophrenia-spectrum pathology in 32 men with this syndrome in comparison with 26 healthy controls. This may have implications for treatment of Klinefelter's syndrome and suggests that the X chromosome may be involved in the aetiology of schizophrenia.
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