Complexes of quinolone drugs norfloxacin and ciprofloxacin with alkaline earth metal perchlorates

The interaction of quinolone drugs Norfloxacin (NR) and Ciprofloxacin (CP) with magnesium, calcium and barium perchlorates was investigated. Solid complexes, obtained as products of this interaction, were isolated and characterized by elemental and thermal analysis, FT-IR spectral and electrical conductivity measurements. The spectral studies of the isolated complexes suggest that NR and CP act as bidentate ligands that bind through one carboxylic oxygen atom and the exocyclic carbonyl oxygen atom. The obtained results indicate the formation of the complexes of the following formulas: [M(CP)(2)](ClO4)(2)center dot xH(2)O and [M(NR)(2)](ClO4)(2)center dot xH(2)O, where M = Mg(II), Ca(II), and Ba(II).