Journal
INTERNATIONAL JOURNAL OF PHARMACEUTICS
Volume 496, Issue 2, Pages 984-992Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijpharm.2015.10.081
Keywords
Green chemistry; Graphene oxide; Reduced graphene oxide; Drug carrier
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Funding
- National Natural Science Foundation of China (NSFC) [21373126]
- Fundamental Research Funds of Shandong University [2015JC003]
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A green and mild approach for the preparation of reduced graphene oxide (rGO) was proposed by using riboflavin-5'-phosphate sodium salt dihydrate as a reducing reagent and stabilizer without any other reagent. The fabricated nano-rGO was systematically evaluated for its application as nano-carrier for pH-sensitive drug delivery. The hemolytic toxicity test indicated the as-prepared nano-rGO had negligible hemolytic activity, which demonstrating its safety in drug delivery system. Doxorubicin hydrochloride (DOX) as a model drug was successfully attached onto the surface of nano-rGO via strong pi-pi stacking interaction. Compared with common carriers, the obtained DOX-loaded nano-rGO nanohybrid exhibited characteristics of high drug loading content, good stability, pH-sensitive and sustainable release of drugs. Cytotoxicity assay results suggested such nanohybrid exhibited effective cytotoxicity to MCF-7 and A549 cells by nonspecific endocytosis mechanism. Therefore, the present green fabricated rGO could be a good candidate as an ideal nano-carrier for drug delivery and controlled release. (C) 2015 Elsevier B.V. All rights reserved.
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