Journal
INTERNATIONAL JOURNAL OF PHARMACEUTICS
Volume 488, Issue 1-2, Pages 136-153Publisher
ELSEVIER
DOI: 10.1016/j.ijpharm.2015.04.053
Keywords
Spray freeze drying; Protein formulations; Lyophilisation; Porous particles; Pulmonary application; Vaccination
Categories
Funding
- Deutsche Forschungsgemeinschaft (DFG) [LA1362/2]
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Pharmaceutical spray-freeze drying (SFD) includes a heterogeneous set of technologies with primary applications in apparent solubility enhancement, pulmonary drug delivery, intradermal ballistic administration and delivery of vaccines to the nasal mucosa. The methods comprise of three steps: droplet generation, freezing and sublimation drying, which can be matched to the requirements given by the dosage form and route of administration. The objectives, various methods and physicochemical and pharmacological outcomes have been reviewed with a scope including related fields of science and technology. (C) 2015 Elsevier B.V. All rights reserved.
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