Journal
JOURNAL OF NEURO-ONCOLOGY
Volume 80, Issue 2, Pages 133-142Publisher
SPRINGER
DOI: 10.1007/s11060-006-9173-6
Keywords
LRRC4; U251 cells; invasion; RPTP-zeta
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LRRC4 (leucine rich repeat containing 4), a novel member of LRP (Leucine-rich repeat protein) superfamily, contains a conserved leucine-rich repeat (LRR) cassette and an immunoglobulin-like (IgC2) domain in its extracellular region. In the present study, we demonstrated that the N and C terminal LRR (LRRNT and LRRCT) are requisite for membrane and cytoplasm location of LRRC4 in Cos7 cells. We also suggested that RPTP-zeta (receptor-type protein tyrosine phosphatase) receptor is relevant to the invasion ability of gliomas cells, and its expression is inhibited by the reexpression of LRRC4. Our observations indicated that LRRC4 may be a negative regulator of the RPTP-zeta receptor, and contribute to suppressing the invasion ability of gliomas cells.
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