Journal
JOURNAL OF VIROLOGY
Volume 80, Issue 21, Pages 10871-10873Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.01308-06
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Funding
- NCI NIH HHS [5P01 CA87661, P01 CA087661] Funding Source: Medline
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Pseudorabies virus (PRV), an alphaherpesvirus related to herpes simplex virus type 1 and varicella-zoster virus, infects a broad host range of mammals. A striking characteristic of PRV infection is the different symptoms and outcomes of infection in natural and nonnatural hosts. Adult pigs, the natural hosts of PRV, survive infection with only mild respiratory symptoms, while nonnatural hosts, including rodents and cattle, invariably die after exhibiting neurological symptoms. Here, we show that the PRV EPO protein is necessary to overcome an interferon-mediated antiviral response in primary cells from the natural host of PRV but is not necessary in nonnatural-host cells.
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