Journal
BIOCHEMICAL SOCIETY TRANSACTIONS
Volume 34, Issue -, Pages 953-956Publisher
PORTLAND PRESS LTD
DOI: 10.1042/BST0340953
Keywords
cell death; mitochondrion; peroxynitrite; reactive nitrogen species; reactive oxygen species
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ROS (reactive oxygen species) and RNS (reactive nitrogen species) are central to the innate immunity that protects us from infection, but also contribute to degenerative diseases and possibly aging. However, ROS and RNS are increasingly recognized to contribute to physiological signalling. This review briefly describes the main interactions between ROS and RNS and shows how their origins, chemistry, metabolism and biological actions are intimately linked.
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