Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 103, Issue 45, Pages 16942-16947Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0606863103
Keywords
disease protection; opsonophagocytosis; reverse vaccinology
Categories
Funding
- NIAID NIH HHS [AI 38897, R01 AI052474, AI 52474, R01 AI038897] Funding Source: Medline
Ask authors/readers for more resources
Staphylococcus aureus is the most common cause of hospital-acquired infection. Because of the emergence of anti biotic-resistant strains, these infections represent a serious public health threat. To develop a broadly protective vaccine, we tested cell wall-anchored surface proteins of S. aureus as antigens in a murine model of abscess formation. Immunization with four antigens (IsdA, IsdB, ScIrD, and SdrE) generated significant protective immunity that correlated with the induction of opsonophagocytic antibodies. When assembled into a combined vaccine, the four surface proteins afforded high levels of protection against invasive disease or lethal challenge with human clinical S. aureus isolates.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available