Journal
NANO LETTERS
Volume 6, Issue 11, Pages 2383-2386Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nl0617179
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Funding
- NCI NIH HHS [N01 CO037123, N01-CO-37123] Funding Source: Medline
- NIAID NIH HHS [N01CO37123] Funding Source: Medline
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We describe here a nontoxic two-photon photodynamic nanoparticle platform and its cellular application. We demonstrate that the dye's potential toxicity can be circumvented by its permanent encapsulation into a biocompatible nanoparticle polymer matrix; this was examined by dye leaching experiments and confirmed by cell uptake experiments. Infrared two-photon nanoplatform phototoxicity was demonstrated for rat C6 glioma cells, while the controls showed no dark toxicity for these living cells.
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