Journal
NEURON
Volume 52, Issue 3, Pages 437-444Publisher
CELL PRESS
DOI: 10.1016/j.neuron.2006.08.024
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Funding
- Medical Research Council [MC_U117512674] Funding Source: Medline
- Medical Research Council [MC_U117512674] Funding Source: researchfish
- MRC [MC_U117512674] Funding Source: UKRI
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Arc/Arg3.1 is robustly induced by plasticity-producing stimulation and specifically targeted to stimulated synaptic areas. To investigate the role of Arc/Arg3.1 in synaptic plasticity and learning and memory, we generated Arc/Arg3.1 knockout mice. These animals fail to form long-lasting memories for implicit and explicit learning tasks, despite intact short-term memory. Moreover, they exhibit a biphasic alteration of hippocampal long-term potentiation in the dentate gyrus and area CA1 with an enhanced early and absent late phase. In addition, long-term depression is significantly impaired. Together, these results demonstrate a critical role for Arc/Arg3.1 in the consolidation of enduring synaptic plasticity and memory storage.
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