4.8 Article

Direct palladium-catalyzed ortho-arylation of benzylamines

Journal

ORGANIC LETTERS
Volume 8, Issue 23, Pages 5211-5213

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol061919b

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Unsubstituted benzylamines and N-methylbenzylamine can be ortho-arylated under palladium catalysis at 130 degrees C. The reactions require the presence of trifluoroacetic acid and silver acetate.

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