Journal
INTERNATIONAL JOURNAL OF PHARMACEUTICS
Volume 485, Issue 1-2, Pages 164-170Publisher
ELSEVIER
DOI: 10.1016/j.ijpharm.2015.02.067
Keywords
Thiazolidinedione-8; Quorum sensing; Catheter-associated infections; Varnish; Modeling; Sustained release
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Thiazolidinedione-8 (TZD-8) is an anti-quorum-sensing molecule that has the potential to effectively prevent catheter-associated urinary tract infections, a major healthcare challenge. Sustained-release drug-delivery systems can enhance drugs' therapeutic potential, by maintaining their therapeutic level and reducing their side effects. Varnishes for sustained release of TZD-8 based on ethylcellulose or ammonio methacrylate copolymer type A (Eudragit (R) RL) were developed. The main factors affecting release rate were found to be film thickness and presence of a hydrophilic or swellable polymer in the matrix. The release mechanism of ethylcellulose-based systems matched the Higuchi model. Selected varnishes were retained on catheters for at least 8 days. Sustained-release delivery systems of TZD-8 were active against Candida albicans biofilms. The present study demonstrates promising results en route to developing applications for the prevention of catheter-associated infections. (C) 2015 Elsevier B.V. All rights reserved.
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