4.4 Article

Dehydroxymethylation: an unusual reverse reaction of nucleophilic addition to formaldehyde

Journal

TETRAHEDRON LETTERS
Volume 47, Issue 46, Pages 8175-8178

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2006.09.017

Keywords

dehvdroxymethylation; retro-aldol reaction; primary alcohol; formaldehyde

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An unusual dehydroxymethylation has been observed in an acyclic primary alcoholic system. The relief of steric congestion is considered as the primary driving force in this reaction. (c) 2006 Elsevier Ltd. All rights reserved.

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