Synthesis of a hydrophilic and non-ionic anthracene derivative, the N,N′-di-(2,3-dihydroxypropyl)-9,10-anthracenedipropanamide as a chemical trap for singlet molecular oxygen detection in biological systems

We report herein the synthesis of a new hydrophilic and non-ionic anthracene derivative, the N,N'-di-(2,3-dihydroxypropyl)-9,10-anthracenedipropanamide. The evaluation of this compound as chemical trap of singlet molecular oxygen by using labeling experiments and HPLC-MS analysis showed that it could be efficiently used in biological investigations. (c) 2006 Elsevier Ltd. All rights reserved.