Journal
JOURNAL OF IMMUNOLOGY
Volume 177, Issue 10, Pages 6573-6578Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.177.10.6573
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Funding
- Intramural NIH HHS Funding Source: Medline
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The immune system requires precise regulation of activating and inhibitory signals so that it can mount effective responses against pathogens while ensuring tolerance to self-components. Some of the most potent activation signals are triggered by innate immune molecules, particularly those in the TLR family. Recent studies have shown that engagement of TLRs plays a significant role in both innate and adaptive immunity. This review focuses on the ways that TLR function might contribute to the etiology of lupus-like syndromes in the context of an autoimmune-prone environment. By considering the sources, localization, and expression of both nucleic acids and the molecules that bind them, we discuss several ways that innate immunity can play a role in the development of systemic autoimmunity.
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