Journal
INTERNATIONAL JOURNAL OF PHARMACEUTICS
Volume 325, Issue 1-2, Pages 140-146Publisher
ELSEVIER
DOI: 10.1016/j.ijpharm.2006.06.012
Keywords
solid lipid nanoparticles; dextran methacrylate; photochemical cross-linking reaction; ibuprofen; controlled release
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Solid lipid nanoparticles (SLN) containing or not (S)-(+)-2-(4-isobutylphenyl)propionic acid (ibuprofen) were prepared with Preciol ATO 5 as lipid phase by the hot homogenization technique and characterized through particle size analyses and zeta potential measurements. DSC experiments carried out on the freeze-dried samples of loaded SLN showed a shift of the melting endotherm of the lipid phase, with the maximum at a temperature value higher then that of theempty SLN. H-1 NMR of the nanosuspension allowed to calculate the encapsulation efficiency of the particles that was 52 +/- 3%. By adding dextran methacrylate (DEX-MA) to the aqueous phase and submitting the mixture to UV irradiation, systems of SLN (drug-loaded and unloaded) incorporated into a dextran hydrogel were prepared. Finally, dissolution studies of ibuprofen from the freeze-dried samples were performed. The comparison among the release profiles of ibuprofen from SLN, DEX-MA hydrogel and SLN/DEX-MA-hydrogel allows to affirm that this last system, retaining about 60% of the drug after 2 h in acid medium and releasing it slowly in neutral solution, is suitable for modified delivery oral formulations. (c) 2006 Elsevier B.V. All rights reserved.
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