Journal
ADVANCED DRUG DELIVERY REVIEWS
Volume 58, Issue 11, Pages 1136-1163Publisher
ELSEVIER
DOI: 10.1016/j.addr.2006.07.024
Keywords
transporter; corneal epithelium; retinal pigment epithelium; retinal capillaries; ocular drug delivery; ocular pharmacokinetics
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Corneal epithelium and blood-retina barrier (i.e. retinal capillaries and retinal pigment epithelium (RPE)) are the key membranes that regulate the access of xenobiotics into the ocular tissues. Corneal epithelium limits drug absorption from the lacrimal fluid into the anterior chamber after eyedrop administration, whereas blood-retina barrier restricts the entry of drugs from systemic circulation to the posterior eye segment. Like in general pharmacokinetics, the role of transporters has been considered to be quite limited as compared to the passive diffusion of drugs across the membranes. As the functional role of transporters is being revealed it has become evident that the transporters are widely important in pharmacokinetics. This review updates the current knowledge about the transporters in the corneal epithelium and blood-retina barrier and demonstrates that the information is far from complete. We also show that quite many ocular drugs are known to interact with transporters, but the studies about the expression and function of those transporters in the eye are still sparse. Therefore, the transporters probably have greater role in ocular pharmacokineties than we currently realise. (c) 2006 Elsevier B.V. All rights reserved.
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