Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 16, Issue 22, Pages 5844-5848Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2006.08.065
Keywords
anticancer; chalcone; tubulin; fluorine; fluorination
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Chalcones are known to exhibit antimitotic properties caused by inhibition of tubulin polymerisation. We describe here the effects of different alpha-substitutions, in particular alpha-fluorination, on the structure and biological activity of a series of chalcones. (c) 2006 Elsevier Ltd. All rights reserved.
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