Journal
GENES & DEVELOPMENT
Volume 20, Issue 22, Pages 3079-3083Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.405306
Keywords
vernalization response; natural variation; FLC; epigenetic silencing; histone modification; adaptation
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Funding
- Biotechnology and Biological Sciences Research Council [BBS/E/J/00000581] Funding Source: researchfish
- Biotechnology and Biological Sciences Research Council [BBS/E/J/00000581] Funding Source: Medline
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Vernalization, the cold-induced acceleration of flowering, involves the epigenetic silencing of the floral repressor gene FLOWERING LOCUS C (FLC). We investigated the molecular basis for variation in vernalization in Arabidopsis natural accessions adapted to different climates. A major variable was the degree to which different periods of cold caused stable FLC silencing. In accessions requiring long vernalization, FLC expression was reactivated following nonsaturating vernalization, but this reactivation was progressively attenuated with increasing cold exposure. This response was correlated with the rate of accumulation of FLC histone H3 Lys 27 trimethylation (H3K27me3). Thus, variation in epigenetic silencing of FLC appears to have contributed to Arabidopsis adaptation.
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