Journal
INTERNATIONAL JOURNAL OF PHARMACEUTICS
Volume 494, Issue 1, Pages 264-270Publisher
ELSEVIER
DOI: 10.1016/j.ijpharm.2015.08.035
Keywords
Hydrogel; Silk fibroin; Copolymers; Composite system; Controlled release
Categories
Funding
- Second Phase of Jiangsu Universities' Distinctive Discipline Development Program for Textile Science and Engineering of Soochow University
- Key Laboratory of Eco-Textiles, Ministry of Education, Jiangnan University [KLET1005]
Ask authors/readers for more resources
In the present study, a composite system for the controlled and sustained release of hydrophobic/ hydrophilic drugs is described. Composite hydrogels were prepared by blending silk fibroin (SF) with PLA-PEG-PLA copolymer under mild aqueous condition. Aspirin and indomethacin were incorporated into SF/Copolymer hydrogels as two model drugs with different water-solubility. The degradation of composite hydrogels during the drug release was mainly caused by the hydrolysis of copolymers. SF with stable beta-sheet-rich structure was not easily degraded which maintained the mechanical integrity of composite hydrogel. The hydrophobic/hydrophilic interactions of copolymers with model drugs would significantly alter the morphological features of composite hydrogels. Various parameters such as drug load, concentration ratio, and composition of copolymer were considered in vitro drug release. Aspirin as a hydrophilic drug could be controlled release from composite hydrogel at a constant rate for 5 days. Its release was mainly driven by diffusion-based mechanism. Hydrophobic indomethacin could be encapsulated in copolymer nanoparticles distributing in the composite hydrogel. Its sustained release was mainly degradation controlled which could last up to two weeks. SF/Copolymer hydrogel has potential as a useful composite system widely applying for controlled and sustained release of various drugs. (C) 2015 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available