Journal
INTERNATIONAL JOURNAL OF PHARMACEUTICS
Volume 478, Issue 2, Pages 788-795Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijpharm.2014.12.001
Keywords
Curcumin; Gelatin; Nanogels; pH sensitive; Bioavailability; Anticancer drug delivery
Categories
Funding
- Ministry of Science, ICT & Future Planning, Korea
- Acceleration Research program [2014R1A2A1A11054584]
- Pioneer Research Center Program [2010-0019308/2010-0019482]
- Brain Korea 21 Plus Program [21A2013800002]
- National Research Foundation of Korea [2010-0019482, 2014R1A2A1A11054584] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Ask authors/readers for more resources
Interpenetrating polymeric network nanogels (IPN-NGs) composed of natural gelatin biological protein macromolecules and poly(acrylamidoglycolic acid) were produced by simple free radical emulsion polymerization. The developed IPN-NGs were characterized by Fourier-transform infra-red spectroscopy to confirm the formation of NGs. The hydrophobic curcumin drug was loaded successfully into these NGs using an in-situ method. The curcumin-encapsulated NGs were well dispersed in aqueous solutions and showed good bioavailability. Curcumin was dispersed molecularly in the IPN-NGs, which was confirmed by differential scanning calorimetry and X-ray diffraction. The NGs exhibited pH sensitive properties according to dynamic light scattering and the zeta size potentials. Transmission electron microscopy revealed the NGs to be spherical, approximately 100 nm in size. The encapsulation efficiency of these IPNNGs drug formulations ranged from 42 to 48%. In addition, the release of curcumin from the NGs was examined in phosphate buffer medium. The cytotoxicity of the IPN-NGs was studied using in vitro cultures of fibroblasts and a colorectal cancer cell line. The results suggest that the newly developed pH sensitive gelatin-poly(acrylamidoglycolic acid)-curcumin NGs can be applied for colorectal cancer drug delivery applications. (C) 2014 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available