Journal
JOURNAL OF BIOLOGICAL CHEMISTRY
Volume 281, Issue 46, Pages 34973-34981Publisher
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.M607018200
Keywords
-
Categories
Ask authors/readers for more resources
The members of the NF-kappa B transcription factor family are key regulators of gene expression in the immune response. Different combinations of NF-kappa B subunits not only diverge in timing to induce transcription but also recognize varying sequences of the NF-kappa B-binding site of their target genes. The p52 subunit is generated as a result of processing of NF-kappa B2 p100. Here, we demonstrate that the non-canonical I kappa B kinase is an element of(IKK is an element of) directly interacts with p100. In a transactivation assay, IKK is an element of promoted the ability of p52 to transactivate gene expression. This effect was indirect, requiring p65, which was shown to be part of the IKK is an element of-p52 complex and to be phosphorylated by IKK is an element of. These novel interactions reveal a hitherto unknown function of IKK is an element of in the regulation of the alternative NF-kappa B activation pathway involving p52 and p65.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available