Journal
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume 350, Issue 2, Pages 298-306Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2006.09.033
Keywords
manganese; Mn2+; MRI; oxyntomodulin; glucagon-like peptide-1; hypothalamus; obesity; gut peptides; appetite; proglucagon
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Funding
- Medical Research Council [G7811974, G108/535, MC_U120061305] Funding Source: researchfish
- National Institute for Health Research [03/DHCS/03/G121/48] Funding Source: researchfish
- Medical Research Council [G108/535, G7811974, MC_U120061305] Funding Source: Medline
- Wellcome Trust Funding Source: Medline
- MRC [G108/535, MC_U120061305, G7811974] Funding Source: UKRI
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The anorexigenic gut hormones oxyntomodulin (OXM) and glucagon-like peptide-I (GLP-1) are thought to physiologically regulate appetite and food intake. Using manganese-enhanced magnetic resonance imaging, we have shown distinct patterns of neuronal activation in the hypothalamus in response to intraperitoneal injections into fasted mice of 900 and 5400 nmol/kg OXM or 900 nmol/kg GLP1. Administration of OXM at either dose resulted in a reduced rate of signal enhancement, reflecting a reduction in neuronal activity, in the arcuate, paraventricular, and supraoptic nuclei of the hypothalamus. Conversely, GLP-I caused a reduction in signal enhancement in the paraventricular nucleus only and an increase in the ventromedial hypothalamic nucleus. Our data show that these two apparently similar peptides generate distinct patterns of activation within the hypothalamus, suggesting that GLP-1 and OXM may act via different hypothalamic pathways. (c) 2006 Elsevier Inc. All rights reserved.
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