Journal
BRITISH JOURNAL OF CANCER
Volume 95, Issue 10, Pages 1410-1414Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.bjc.6603444
Keywords
c-Src; breast cancer; DCIS; immunohistochemistry; HER2
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Funding
- Breast Cancer Now [2006MAYSF01] Funding Source: Medline
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Overexpression and/or activity of c-Src non-receptor tyrosine kinase is associated with progression of several human epithelial cancers including breast cancer. c-Src activity in 'pure' ductal carcinoma in situ ( DCIS) was measured to assess whether this predicts recurrence and/or correlates with HER2 expression and other clinical parameters. Activated c-Src levels were evaluated in DCIS biopsies from 129 women, with median follow-up at 60 months. High levels of activated c-Src correlated with HER2 positivity, high tumour grade, comedo necrosis and elevated epithelial proliferation. In univariate analysis, high activated c-Src level associated with lower recurrence-free survival at 5 years (P=0.011). Thus, high c-Src activity may identify a subset of DCIS with high risk of recurrence or progression to invasive cancer where therapeutics targeting c-Src may benefit this patient subset.
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