Journal
INTERNATIONAL JOURNAL OF PHARMACEUTICS
Volume 483, Issue 1-2, Pages 244-249Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijpharm.2014.12.034
Keywords
Inkjet printing; Personalized medicine; Cellulose carrier substrates; Near infrared hyperspectral imaging; Quality control; Multivariate analysis
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Funding
- Finnish Cultural Foundation
- TEKES - the Finnish Funding Agency for Innovation
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The aim of the study was to investigate applicability of near infra-red (NIR) hyperspectral imaging technique in quality control of printed personalised dosage forms. Inkjet printing technology was utilized to fabricate escalating doses of an active pharmaceutical ingredient (API). A solution containing anhydrous theophylline as the model drug was developed as a printable formulation. Single units solid dosage forms (SDFs) were prepared by jetting the solution onto 1 cm x 1 cm areas on carrier substrate with multiple printing passes. It was found that the number of printing passes was in excellent correlation (R-2 = 0.9994) with the amount of the dispensed drug (mu gcm (2)) based on the UV calibration plot. The API dose escalation was approximately 7.5 mu g cm (2) for each printing pass concluding that inkjet printing technology can optimally provide solutions to accurate deposition of active substances with a potential for personalized dosing. Principal component analysis (PCA) was carried out in order to visualize the trends in the hyperspectral data. Subsequently, a quantitative partial least squares (PLS) regression model was created. NIR hyperspectral imaging proved (R-2 = 0.9767) to be a reliable, rapid and non-destructive method to optimize quality control of these planar printed dosage forms. (C) 2015 Elsevier B.V. All rights reserved.
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