Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 103, Issue 47, Pages 17944-17948Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0607497103
Keywords
enclothelial nitric oxide synthase; myocardial infarction; stroke
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Funding
- NINDS NIH HHS [P01 NS035965, NS35965] Funding Source: Medline
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Neuroglobin (Ngb), a protein related to myoglobin and hemoglobin but expressed predominantly in the brain, is induced by neuronal hypoxia and cerebral ischemia and protects against hypoxic or ischemic neuronal injury. We engineered transgenic mice that overexpress murine Ngb under the control of a chicken beta-actin promoter, resulting in enhanced Ngb expression in multiple cell types and multiple tissues, including brain and heart. In Ngb-overexpressing transgenic mice compared with wild-type littermates, the volume of cerebral infarcts after occlusion of the middle cerebral artery was reduced by approximate to 30%, and the volume of myocardial infarcts produced by occlusion of the left anterior descending coronary artery was reduced by approximate to 25%. Ngb overexpression was associated with enhanced expression of endothelial nitric oxide synthase in vascular endothelial cells. These findings extend prior evidence for cytoprotection by Ngb and suggest both direct (parenchymatous) and indirect (vasomotor) protective mechanisms.
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