Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 103, Issue 47, Pages 17667-17671Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0608803103
Keywords
bactericidal; hydrophobic polyions; virucidal coatings; polyethylenimine; flu
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Funding
- NIAID NIH HHS [AI56267, AI69208, R01 AI069208, R01 AI056267] Funding Source: Medline
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Painting a glass slide with branched or linear NN-dodecyl methyl-polyethylenimines (PEIs) and certain other hydrophobic PEI derivatives enables it to kill influenza virus with essentially a 100% efficiency (at least a 4-log reduction in the viral titer) within minutes, as well as the airborne human pathogenic bacteria Escherichia coli and Staphyiococcus aureus. For most of the coating polyions, this virucidal action is shown to be on contact, i.e., solely by the polymeric chains anchored to the slide surface; for others, a contribution of the polyion leaching from the painted surface cannot be ruled out. A relationship between the structure of the derivatized PEI and the resultant virucidal activity of the painted surface has been elucidated.
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