Journal
ORGANIC LETTERS
Volume 8, Issue 24, Pages 5461-5463Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol062061t
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In the presence of thiols, the ten-membered-ring enediyne calicheamicin gamma(l)(1) generates a p-benzyne biradical that initiates oxidative cleavage of double-stranded DNA. Application of spin-trapping has successfully provided ESR and mass spectroscopic evidence for the formation of the monoadducts with phenyl tert-butyl nitrone (PBN).
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