Journal
ORGANIC LETTERS
Volume 8, Issue 24, Pages 5449-5452Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol062041r
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Inhibition of protein synthesis is one of the validated and highly successful targets for inhibition of bacterial growth; this mechanism is a target of a large number of clinical drugs. Ribosomal protein S4, a primary protein, is a potential target for the discovery of antibacterial agents. We describe, using an antisense-sensitized rpsD Streptomyces aureus strain, the discovery and activity of lucensimycins A and B.
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