4.7 Article

Suzuki-Miyaura cross-coupling reactions of benzyl halides with potassium aryltrifluoroborates

Journal

JOURNAL OF ORGANIC CHEMISTRY
Volume 71, Issue 24, Pages 9198-9202

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/jo061699f

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Funding

  1. NCRR NIH HHS [S10 RR016640-01] Funding Source: Medline
  2. NIGMS NIH HHS [R01 GM035249-22, GM35249, R01 GM035249] Funding Source: Medline

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[GRAPHICS] The palladium-catalyzed cross-coupling of potassium aryltrifluoroborates with benzylic halides occurs in good yield with high functional group tolerance. The increased stability of potassium aryltrifluoroborates compared to other boron coupling partners makes this an effective route to functionalized methylene-linked biaryl systems.

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