Journal
TETRAHEDRON
Volume 62, Issue 48, Pages 11178-11186Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2006.09.021
Keywords
bile acid; fluconazole/bile acid conjugate; click chemistry; antifungal agent; 1,2,3-triazole
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Novel fluconazole/bile acid conjugates were designed and their regioselective synthesis was achieved in very high yield via Cu(I) catalyzed intermolecular 1,3-dipolar cycloaddition. These new molecules showed good antifungal activity against Candida species. (c) 2006 Elsevier Ltd. All rights reserved.
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