Journal
NEUROSCIENCE LETTERS
Volume 409, Issue 1, Pages 1-4Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2006.07.009
Keywords
Alzheimer's disease; cerebrospinal fluid; Tau; amyloid; quality control
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Currently, neurochemical dementia diagnostics (NDD) are increasingly entering routine clinical neurochemistry, offering improved early and differential diagnosis of dementias. However, there is an obvious lack of standardization in pre-analytical sample handling and systematic quality surveys. Therefore, in this study, 14 laboratories in Germany, Austria, and Switzerland were given aliquots of a human cerebrospinal fluid (CSF) sample, and were asked to measure Alzheimer's disease (AD) biomarkers (amyloid beta (A beta) peptides, total Tau protein, and phosphorylated Tau protein (P-tau(181P))) according to their routine protocols. Results: The inter-laboratory coefficients of variation of the results obtained by the laboratories participating in this study were in the range of 20-30%. Although the results of this quality control survey are promising, the quality of measurements has to be further optimized. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
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