Journal
FEBS LETTERS
Volume 580, Issue 27, Pages 6442-6446Publisher
WILEY
DOI: 10.1016/j.febslet.2006.10.066
Keywords
Dmrt7; knockout mouse; male infertility; spermatogenesis; testis
Ask authors/readers for more resources
Genes including DM domain regulate sexual development in diverse metazoan phyla. One of these genes, Dmrt7, was expressed only in testes of adult mice. To determine the role of Dmrt7 in mice, we generated Dmrt7-knockout mice (Dmrt7(-/-)). Although the Dmrt7(-/-) showed normal growth, null males were infertile. No sperm was detected in the epididymis of Dmrt7(-/-) adult males. Absence of spermatids in a histological analysis, decreased expression of Ccna1 mRNA and the accumulation of SCP3-positive spermatocytes showed the arrest of spermatogenesis at the pachytene stage in the Dmrt7-knockout mice. (c) 2006 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available