Journal
CANCER LETTERS
Volume 244, Issue 1, Pages 24-33Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2005.11.038
Keywords
LRH-1; breast cancer; steroidogenesis
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Liver receptor homologue-1 (LRH-1) belongs to a class of nuclear orphan receptor. We examined immunolocalization of LRH-1 in 106 breast carcinomas. LRH-1 immunoreactivity was detected in 43% of the invasive ductal carcinoma. It was negatively correlated with clinical stage, histological grade and HER2 status, and positively associated with sex-steroid receptors, steroidogenic acute regulatory protein, P450 side-chain cleavage, and 3 beta-hydroxysteroid dehydrogenase. LRH-1 immunoreactivity was also detected in 28% of the ductal carcinoma in situ. These results suggest that LRH-1 is frequently detected in breast carcinoma tissues, and plays important roles including the regulation of in situ steroidogenesis. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
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