Journal
PSYCHIATRY RESEARCH
Volume 145, Issue 1, Pages 75-78Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.psychres.2006.05.020
Keywords
electroconvulsive shock; ERK; BDNF
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The effects of chronic electroconvulsive shock (ECS), given daily for 1, 5 and 10 days, on the activation of extracellular signal-regulated kinase (ERK) were studied in the rat frontal cortex. The phosphorylation of MEK1/2 and ERK1/2 increased through 5 days of ECS. Thereafter, a plateau was achieved. The expression of brain-derived neurotrophic factor was continuously increased for 10 days. Our data show that the effect of ECS on ERK1/2 signaling is increased with chronic treatment. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
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