Journal
JOURNAL OF BIOCHEMICAL AND BIOPHYSICAL METHODS
Volume 69, Issue 1-2, Pages 151-161Publisher
ELSEVIER
DOI: 10.1016/j.jbbm.2006.02.006
Keywords
dendrimer; cisplatin; platinum; infrared spectroscopy
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Three generations of alpha,gamma-diaminobutyric acid modified poly(propyleneimine) dendrimers [DAB(AM)(n), n=4, 8, 16] containing 4, 8, 16 free amino groups were coupled with Boc-protected alpha,gamma-diaminobutyric acid (DABA) moieties in high yields. These modified dendrimers were deprotected and the chiral dendritic amines with 8, 16 and 32 amino groups on the surface were isolated in excellent yields. Dendrimers with cisplatin moieties at the periphery were obtained in the reaction of the free amine dendrimers and potassium tetrachloroplatinate(II). The highly insoluble complexes were isolated as hydrates and characterized by means of IR, TGA and elemental analysis. (c) 2006 Elsevier B.V. All rights reserved.
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