Journal
NATURE CLINICAL PRACTICE RHEUMATOLOGY
Volume 2, Issue 12, Pages 671-678Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ncprheum0349
Keywords
affective spectrum disorder; fibromyalgia; genetics; irritable bowel syndrome; post-traumatic-stress disorder
Categories
Ask authors/readers for more resources
Fibromyalgia is characterized by widespread pain and tenderness, and has a significant familial component. The etiology of fibromyalgia remains unclear, but genetic factors seem to have a significant role, and are influenced by environmental factors. Research over the past two decades has demonstrated that genetic polymorphisms in the serotoninergic, doparninergic and catecholarninergic systems of pain transmission and processing are involved in the etiology of fibromyalgia, but additional candidates continue to emerge. Fibromyalgia is thought to belong to the group of affective spectrum disorders, which include related psychiatric and medical disorders. As the concept of affective spectrum disorders continues to evolve, progress in the understanding of the genetic basis of related functional disorders, such as irritable bowel syndrome and post-traumatic-stress disorder, is aiding our understanding of the genetic basis of fibromyalgia.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available