Journal
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
Volume 602, Issue 1-2, Pages 100-109Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.mrfmmm.2006.08.008
Keywords
homologous recombination frequency (HRF); recombination rate (RR); beta-glucuronidase; Arabidopsis thaliana; Nicotiana tabacum; UVB
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Environmental factors that damage DNA have various lengths of exposure and intensity levels. Although the results of increasing the intensity of a DNA damaging agent is often predictable, it is not clear whether the stage during development when the exposure is received has any influence on the amount of DNA damage. In this paper we analyzed the influence of UVB on the stability of Arabidopsis thaliana and the Nicotiana tabacum genomes. Our experiments showed that the acute exposure to IJVB produces a significantly greater increase in homologous recombination frequency (HRF) and recombination rate (RR) compared with that produced by chronic exposure. The increase in HRF showed a positive correlation with UVB dose and a negative correlation with plant age. In other words, as the UVB dose was increased, there was a concomitant increase in HRR Conversely, older plants had a lower HRF increase as compared to younger plants. Our experiments suggest that exposure to IJVB makes the most significant impact on genome stability during the early stages of plant development. (c) 2006 Elsevier B.V. All rights reserved.
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