Journal
BIOLOGICAL PSYCHIATRY
Volume 60, Issue 11, Pages 1181-1187Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.biopsych.2005.11.028
Keywords
schizophrenia; diffusion tensor imaging; magnetic resonance imaging; frontal lobe; white matter; prefrontal function
Categories
Funding
- NCRR NIH HHS [M01-RR-00071] Funding Source: Medline
- NIMH NIH HHS [MH60023, P50 MH 66392-01] Funding Source: Medline
Ask authors/readers for more resources
Background: Alignment of white matter axons as inferred from diffusion tensor imaging has indicated changes in schizophrenia in frontal and frontotemperoral white matter. Methods. Diffusion tensor anisotropy and anatomical magnetic resonance images were acquired in 64 patients with schizophrenia and 55 normal volunteers. Anatomical images were acquired with a magnetization prepared rapid gradient echo sequence, and fusion tensor images used a pulsed gradient spin-echo acquisition. Images were aligned and warped to a standard brain, and diffusion tensor images used a pulsed gradient spin-echo acquisition. Images were aligned and warped to a standard brain, and anisotropy in normal volunteers and patients was compared using significance probability mapping. Results: Patients showed widespread areas of reduced anisotropy, including the frontal white matter, the corpus callosum, and the frontal longitudinal fasciculus. Conclusions. These findings, which are consistent with earlier reports of frontal decreases in anisotropy, demonstrate that the effects are most prominent in frontal and callosal areas and are particularly widespread in frontal white matter regions.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available