Journal
PHYSIOLOGY
Volume 21, Issue -, Pages 430-439Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/physiol.00032.2006
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Lipid rafts are liquid-ordered (I.) phase microdomains proposed to exist in biological membranes. Rafts have been widely studied by isolating I-o-phase detergent-resistant membranes (DRMs) from cells. Recent findings have shown that DRMs are not the same as preexisting rafts, prompting a major revision of the raft model. Nevertheless, raft-targeting signals identified by DRM analysis are often required for protein function, implicating rafts in a variety of cell processes.
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