Journal
CLINICAL NEUROSCIENCE RESEARCH
Volume 6, Issue 5, Pages 237-245Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.cnr.2006.09.004
Keywords
microglia; TREM; antigen-presentation
Categories
Funding
- NINDS NIH HHS [R01 NS045735-01, R01 NS039508-01A1S1, R01 NS039508-03, R01 NS045735-03, R01 NS039508-05, R01 NS045735-02, R01 NS039508-01A1, R01 NS039508-06, R01 NS045735, R01 NS045735-05, R01 NS039508-02, R01 NS045735-04, R01 NS039508-04, R01 NS039508] Funding Source: Medline
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Neuroinflammation is a complex integration of the responses of all cells present within the CNS, including the neurons, macroglia, microglia and the infiltrating leukocytes. The initiating insult, environmental factors, genetic background and age/past experiences all combine to modulate the integrated response of this complex neuroinflammatory circuit. Here, we explore how these factors interact to lead to either neuroprotective versus neurotoxic inflammatory responses. We specifically focus on microglia and astrocytic regulation of autoreactive T cell responses. (C) 2006 Association for Research in Nervous and Mental Disease. Published by Elsevier B.V. All rights reserved.
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