Journal
BREAST
Volume 15, Issue 6, Pages 754-761Publisher
CHURCHILL LIVINGSTONE
DOI: 10.1016/j.breast.2006.03.008
Keywords
breast cancer; glutathione S-transferase; BRCA; homologous recombination; DNA damage and repair
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In this study, the genetic polymorphisms associated with breast cancer in southern Taiwan were investigated. Two categories of genes were analyzed: (1) BRCA1, BRCA2, and Rad51, the DNA repair factors involved in homologous recombinational repair; and (2) CYP1A1, COMT, GST, and NAT2, the xenobiotic-metabolizing enzymes (XME) involved in estrogen metabolism. We found that the number of deletions and/or mutations in the GST genes was highly correlated with the occurrence of breast cancer. These data suggest that the GST enzymes, which detoxify the catechol estrogen quinones, are important target molecules for screening in populations at high risk of breast cancer. (c) 2006 Elsevier Ltd. All rights reserved.
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