Journal
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
Volume 21, Issue 12, Pages 1187-1192Publisher
JOHN WILEY & SONS LTD
DOI: 10.1002/gps.1639
Keywords
subjective cognitive function; mild cognitive impairment; depression; cognitive decline
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Funding
- NIA NIH HHS [T32 AG020499-03, U01 AG014276, U01 AG14282, U01 AG014263, T32 AG020499, U01 AG014289, U01 AG14276, U01 AG014260, U01 AG014282, U01 AG14289, U01 AG14260, U01 AG14263, T32 AG020499-02, T32 AG020499-04, T32 AG020499-05, T32 AG020499-01A1] Funding Source: Medline
- NINR NIH HHS [U01 NR04508, U01 NR004508, U01 NR04507, U01 NR004507] Funding Source: Medline
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Objective To examine the relationship between subjective cognitive function and subsequent cognitive decline among individuals with psychometrically defined amnestic mild cognitive impairment (MCI), and to determine whether the presence of depressive symptoms modifies this relationship. Method Fifty-five individuals met psychometric criteria for amnestic mild cognitive impairment (MCI). Cognitive decline was measured using the Mini-Mental State Examination (MMSE), which was administered at baseline and at follow-up two years later. Subjective cognitive function was examined using two different one-item memory complaints, as well as a scale focused on current level of cognitive function relative to past function and a scale focused on forgetting in specific everyday situations. Results In multiple regression analyses, the one-item complaint of change in memory at baseline predicted future cognitive decline. There was a significant interaction effect whereby this association was stronger in participants who endorsed fewer symptoms of depression. Conclusion Individuals showing memory deficits consistent with amnestic MCI have at least some insight regarding cognitive decline and the extent to which subjective cognitive function is useful in predicting future decline may depend on what particular questions are asked as well as presence of depressive symptoms. Copyright (c) 2006 John Wiley & Sons, Ltd.
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