Journal
MOLECULAR CANCER RESEARCH
Volume 4, Issue 12, Pages 899-904Publisher
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/1541-7786.MCR-06-0328
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Ubiquitin is an important regulator of diverse biological functions including cell cycle progression, apoptosis, cell proliferation, and DNA damage responses. Crucial proteins involved in the control of such diverse functions are modified by ubiquitin and are frequently altered during oncogenesis. Here, we define such proteins as key-nodes regulated by ubiquitin, discuss examples of their oncogenic aberrations, and indicate how pharmacologic manipulation of such molecular hubs might improve anticancer therapy.
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